Permanent cell (such as cardiac muscle, skeletal muscle)Ĭells affected-Occurs in dividing cells. Mechanism- Result of growth factor-driven proliferation of the mature cell.Ĭells affected- This occurs in non-dividing cells. Mechanism- Result of increased production of cellular protein. Left ventricular hypertrophy (LVH) maybe due to a physiologic response toincreased load, pathologic hypertrophydue to hypertrophic cardiomyopathy(HCM) or be mimicked by myocardialinfiltration. Physiological – hormonal hyperplasia, compensatory hyperplasia. Causes- Increased recruitment of cell from G0 (G Zero) phase of the cell cycle to undergo mitosis. Find more information about Cellular Pathology: Necrosis and apoptosis.
Physiological– hypertrophy of muscle fiber due to increased workload, growth of uterus during pregnancy. (increased volume/mass)Ĭ auses- Either by increased functional demand or by hormonal stimulation. Atrophy caused by pathology includes the following examples.
Each form of hypertrophy is regulated by distinct cellular signalling pathways. Morphology of Cell Injury Adaptive Changes (Atrophy, Hypertrophy, Hyperplasia, Metaplasia. Adolescents and adults who are active in competitive sports often exhibit significant physiological cardiac hypertrophy with left ventricular wall thickness between 13 and 18 mm. Difference between HYPERTROPHY and HYPERPLASIAĭefinition- Is an increase in the size of a parenchymal cell resulting in enlargement of the organ or tissue without any change in the number of cells ( increased size)ĭefinition- This is an increase in the number of parenchymal cells resulting in enlargement of organ and tissue. Hypertrophy initially develops as an adaptive response to physiological and pathological stimuli, but pathological hypertrophy generally progresses to heart failure.
0 kommentar(er)
